Hydroxychloroquine and ocular toxicity recommendations on screening 2009

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    Hydroxychloroquine and ocular toxicity recommendations on screening 2009


    Her rheumatologist instructed her to undergo a baseline ocular examination prior to initiating Plaquenil (hydroxychloroquine, Sanofi-Aventis) therapy. Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. Although the incidence of macular toxicity is infrequent with Plaquenil use (at a dosage of 200mg or 400mg q.d.), its visual impact can be devastating.

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    Retinal toxicity is irreversible and can progress after cessation of hydroxychloroquine, thus early screening is important to limit potential vision loss. Baseline screening and annual screening after five years is recommended. Sep 15, 2014 Hydroxychloroquine sulfate HCQ, Plaquenil is an analogue of chloroquine CQ, an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy. Introduction. Chloroquine CQ and its chemical analogue hydroxychloroquine HCQ -known as antimalarial drugs- have been used commonly since 1950s for the treatment of various autoimmune rheumatic diseases. The efficacy and toxicity of HCQ are lower than those of CQ. Ocular toxicity induced by these drugs was first described in 1957. These drugs are eliminated from the body very slowly.

    Initially, central visual acuity may be unaffected, but the patient may notice related paracentral scotomas that often interfere with reading. The associated classic retinal toxicity is described as a bull’s eye maculopathy (ring of depigmented retinal pigment epithelium that spares the foveal area).

    Hydroxychloroquine and ocular toxicity recommendations on screening 2009

    Hydroxychloroquine Plaquenil Toxicity and., Retinal toxicity associated with chronic exposure to.

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  6. Hydroxychloroquine is a quinolone. The highest tissue distribution is in the choroid and ciliary body of the eye. Hydroxychloroquine is partially metabolized, and 40–50% is excreted by the kidneys. Ocular side effects can be divided broadly into corneal and retinal effects. Corneal side effects include Hudson-Stahli line, verticillata, transient oedema, and decreased sensitivity.

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    Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Chloroquine and hydroxychloroquine 4‐aminoquinolones are used by dermatologists for the treatment of a wide range of disorders. It is widely recognized that their use may lead to ocular complications. The present study shows that nationally set guidelines for the monitoring of ocular toxicity of hydroxychloroquine are not consistently followed by rheumatologists with regard to baseline.

     
  7. Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Can I Take Tylenol With Metoprolol Tartrate? Drugs Details Does plaquenil have a negative effect on metoporol? Hydrochlorothiazide and metoprolol - CardioSmart
     
  8. Narmulь Well-Known Member

    I took my 3rd dose of Plaquenil at supper tonight and 90 minutes later I was rushing to the bathroom. I weighed myself this morning and I'm 2lbs lighter than I was yesterday. If you started any other drugs, this can happen too. I get up extra eaelt, eat, take plaq and then wait for the explosive diarhea before I leave my house. Plaquenil and. diarrhea! rheumatoid Plaquenil Side Effects on Your Eyes and Vision Hydroxychloroquine Uses, Dosage & Side Effects -
     
  9. BigLink Moderator

    Plaquenil - A lot of people have less than 4, or as in my case, more than 4 but spread out over much more than 5 years. So it's very possible for plaquenil to do good without you being considered to have Lupus. I went on plaquenil in 2004 for joint pain, high ANA and pericarditis.

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