This fungus mainly grows in the central, southeastern, and mid-Atlantic states. Most cases of histoplasmosis don’t require treatment. Plaquenil pill shape Plaquenil ms Chloroquine and cancer Plaquenil side effects sensitive gums A 61-year-old truck driver developed a fever, cough, and shortness of breath requiring oxygen support and antibiotics. He had rheumatoid arthritis controlled with methotrexate and hydroxychloroquine. His occupation required delivering produce to and from the Mississippi River Valley to Ontario, Canada. Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia. The lungs are the primary site of histoplasmosis disease, but the infection can spread to many parts of the body. In Olson's study, 46 percent of the patients had severe disseminated disease beyond the lungs. Olson encouraged rheumatoid arthritis patients and physicians to be alert to the possibility of histoplasmosis infection. The disease may progress and spread to other areas of the body. However, people with weaker immune systems may experience serious problems. Hydroxychloroquine with histoplasmosis Histoplasmosis Cause, Types & Complications, Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria Plaquenil baseline examenPlaquenil lucite avisPlaquenil nauseusSide effects plaquenil tablets Presumed Ocular Histoplasmosis Syndrome POHS causes atrophy wasting around the optic nerve and multiple scars, called histo spots, in the choroid. These symptoms are accompanied by new blood vessel growth neovascularization that starts adjacent to a histo spot. Presumed Ocular Histoplasmosis Syndrome - The American.. Histoplasmosis in Rheumatoid Arthritis Patients. Hydroxychloroquine - Side Effects, Dosage, Interactions.. Rheumatoid arthritis is a chronic disorder for which there is no known cure. Fortunately in the last few years, a shift in strategy toward the earlier institution of disease modifying drugs and the availability of new classes of medications have greatly improved the outcomes that can be expected by most patients. Hydroxychloroquine comes as a tablet to take by mouth. For prevention of malaria in adults, two tablets are usually taken once a week on exactly the same day of each week. The first dose is taken 1 to 2 weeks before traveling to an area where malaria is common, and then doses are continued for 8 weeks after exposure. Higher doses of medications that weaken your immune system are more likely to increase your risk of getting a fungal infection. 5,11,13,14. Click on the sections below to see lists of corticosteroids and TNF inhibitors that can increase the chances of getting a fungal infection.