Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Plaquenil macula Plaquenil and epidural anesthesia Can plaquenil cause metallic taste Worsening of Psoriasis and Porphyria Use of Chloroquine phosphate tablets in patients with psoriasis may precipitate a severe attack of psoriasis. When used in patients with porphyria the condition may be exacerbated. Chloroquine phosphate tablets should not be used in these conditions unless the benefit to the patient outweighs the potential. Antimalarials Plaquenil hydroxychloroquine, Quinacrine mepacrine, and chloroquine, used to treat malaria and autoimmune disorders like lupus or rheumatoid arthritis, can induce flares in over 30 percent of people with psoriasis who take them. New or exacerbated symptoms usually occur two to three weeks after starting treatment. Psoriasis is an autoimmune disease. This means that the immune system is not working as it should. In people who do not have psoriasis, the body creates new skin cells and moves them to the. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Chloroquine and psoriasis Hydroxychloroquine Uses, Dosage & Side Effects -, Drugs That Can Trigger or Worsen Psoriasis Plasmodicidal action of chloroquine Exacerbation of Psoriasis due to Hydroxychloroquine Sara S McCoy1*, Vivek Nagaraja2, Scott Paviol3, Johann E Gudjonsson4 and J Michelle Kahlenberg1 1 Department of Internal Medicine, Di-vision of Rheumatology, University of Michigan, USA 2 Department of Internal Medicine, Division of Rheumatology, University of Toledo, USA Exacerbation of Psoriasis due to Hydroxychloroquine. Psoriasis 11 triggers and how to avoid them. Hydroxychloroquine in Psoriasis Is it Really Harmful? HTML.. A 58-year-old man with a 9-year history of psoriasis whose disease was well controlled on twice-weekly PUVA oral methoxsalen and high-intensity long-wave ultraviolet light treatments, experienced a flare of the skin disease while traveling in Brazil. Two Inverse psoriasis causes smooth patches of red, inflamed skin that worsen with friction and sweating. Fungal infections may trigger this type of psoriasis. Pustular psoriasis. This uncommon form of psoriasis can occur in widespread patches generalized pustular psoriasis or in smaller areas on your hands, feet or fingertips. Chloroquine needs to be taken 1-2 weeks before traveling to an area with malaria, compared to some alternatives that can be taken 1-2 days before. chloroquine is only effective against malaria from certain areas of the world. chloroquine may worsen psoriasis, seizures, hearing problems, and liver conditions.