Chloroquine kills sporozoites

Discussion in 'Canada Pharmacy Online' started by mara_payne, 28-Feb-2020.

  1. mejoin XenForo Moderator

    Chloroquine kills sporozoites


    Lets see what the news say and if it’s real or fake news just for scams. The antimalarial drug chloroquine phosphate can’t kill coronavirus directly. It is however being claimed that it can help the body in getting rid of the virus in initial stage.

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    However, the effect of chloroquine on the sporogonic cycle is probably of different nature as the drug does not kill parasites during this stage of development where environment and metabolism are different. Chloroquine has applications other than anti-malarial use, namely as an anti-inflammatory drug. The sporozoites then travel to the liver, where they invade hepatocytes. There, they begin asexual reproduction, also known as schizogony. Over the next 1-2 weeks, P. falciparum, P. malariae, and P. knowlesi sporozoites multiply asexually and mature into merozoites, while host hepatic parenchymal cells die. Volunteers immunized under chloroquine chemoprophylaxis with Plasmodium falciparum sporozoites CPS develop complete, long-lasting protection against homologous sporozoite challenge. Chloroquine affects neither sporozoites nor liver-stages, but kills only asexual forms in erythrocytes once released from the liver into the circulation.

    So as lysosomes inside the white blood cells can get rid of harmful foreign viruses and bacterias entering into the body, thus having more acidity means more ability to disrupt the virus and kill it (or denature it). It’s being claimed that chloroquine increases the acidic properties of the lysosomes inside the cell.

    Chloroquine kills sporozoites

    How does Antimalarial Chloroquine Phosphate help against CoronaVirus., Antimalarials Video, Anatomy, Definition & Function Osmosis

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    In rodent models, sterile protection against malaria can be achieved by the inoculation of intact sporozoites while treating the animals concomitantly with chloroquine, 10 a drug that kills. There’s news floating around that chloroquine phosphate, used as an antimalarial drug, can be helpful in fighting against coronavirus outbreak. Lets see what the news say and if it’s real or fake news just for scams. Can Chloroquine phosphate kill coronavirus? No. The antimalarial drug chloroquine phosphate can’t kill coronavirus directly. Chloroquine is the drug of choice for treating most patients with malaria caused by P. vivax, P. ovale, P. malariae and chloroquine-sensitive strains of P. falciparum. However, due to the development of resistance, chloroquine is ineffective against most strains of P. falciparum in South America, Africa and Asia.

     
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  9. spweb User

    Please see full prescribing information on each of our product pages for FDA-approved indications and dosage. Plaquenil - il Hydroxychloroquine Plaquenil PLAQUENIL HYDROXYCHLOROQUINE SULFATE, USP WARNING PHYSICIANS.
     
  10. markmx Moderator

    Hydroxychloroquine Plaquenil Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria.

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