Trametinib and hydroxychloroquine

Discussion in 'Canada Pharmacy Online' started by devil., 19-Mar-2020.

  1. Worldweb Guest

    Trametinib and hydroxychloroquine


    Researchers from Huntsman Cancer Institute (HCI) at the University of Utah have now come up with a potential new therapy for pancreatic cancer patients. The researchers have found that a new combination therapeutic approach can effectively fight the disease and prolong survival among patients.

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    Dabrafenib, Trametinib and Hydroxychloroquine in Patients With Advanced BRAF Mutant Melanoma BAMM The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Addition of hydroxychloroquine is safe and tolerable with a modest improvement in clinical responses compared to prior studies. Autophagy inhibition may overcome chemotherapy resistance in advanced NSCLC and further study in a more molecularly selected population such as KRAS-positive tumors is warranted. Phase I Trial of Trametinib and Hydroxychloroquine in Patients With Advanced Pancreatic Cancer THREAD Summary The purpose of this phase I trial is to study the side effects and best dose of hydroxychloroquine when given together with trametinib in treating patients with pancreatic cancer that has spread to nearby tissue, lymph nodes or other places in the body and cannot be removed by surgery.

    The results of the study were published in the latest issue of the journal The team has opened up the therapy for clinical trials at HCI as well as other centres across United States along with support from University of California, San Francisco, and Columbia University in New York. The therapy has shown promise in the laboratory set up and now is ready for use among human patients in its clinical trials.

    Trametinib and hydroxychloroquine

    Hydroxychloroquine Side Effects, Dosage, Uses, and More, Phase Ib/II study of hydroxychloroquine in combination with.

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  4. A recent study shows that the combination of MEK inhibitor trametinib and hydroxychloroquine led to a striking disease response in a patient with pancreatic cancer. O'Hara et al. reported the results from a phase II, single arm study in patients with metastatic colon cancer treated with hydroxychloroquine in combination with standard first-line chemotherapy mFOLFOX6 29.

    • Phase Ib/II study of hydroxychloroquine in combination..
    • Phase I Trial of Trametinib and Hydroxychloroquine in..
    • Trametinib C26H23FIN5O4 - PubChem.

    Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. Mar 17, 2019 Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Insufficient data are available in pregnant women exposed to trametinib to assess the risk. Trametinib was embryotoxic and abortifacient in rabbits at doses greater than or equal to those resulting in exposures ~0.3 times the human exposure at the recommended clinical dose. Advise patients of the potential risk to the fetus. Contraception

     
  5. Yulya User

    Chloroquine is a lysosomotropic agent that prevents endosomal acidification [1]. Persistence of chloroquine resistance alleles in malaria. AID 1125562 - Potency index, ratio of ciprofloxacin IC50 to. Chloroquine Side Effects Common, Severe, Long Term -
     
  6. Antimalarial treatment, commonly used with success in rheumatoid arthritis, has sometimes been used to treat psoriatic arthritis. Hydroxychloroquine Oral Uses, Side Effects, Interactions. Hydroxychloroquine Plaquenil Side Effects & Dosage for. Hydroxychloroquine Oral Route Before Using - Mayo Clinic
     
  7. Reaver Moderator

    Hydroxychloroquine - Side Effects, Dosage, Interactions - Drugs. Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America.

    RA and Hydroxychloroquine How Effective is it for.
     
  8. bad1 Well-Known Member

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