One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Photoreceptor integrity line plaquenil On plaquenil icd 10 Chloroquine and hydroxychloroquine bind to melanin in the retinal pigment epithelium RPE and cause damage to the macular cones outside of the fovea. The drugs inhibit RPE lysosome activity, reduce phagocytosis of shed photoreceptor outer segments causing an accumulation of outer receptor segments. In our multiethnic cohort, after a mean of 4.4 years of follow-up, nearly 7% of our patients had developed new integument damage; we have found that, over and above the presence of integument manifestations, higher levels of disease activity were associated with a shorter time-to-integument damage occurrence whereas hydroxychloroquine was. Diarrhea difficulty breathing difficulty seeing at night dizziness or fainting fast, pounding, uneven heartbeat feeling that others are watching you or controlling your behavior feeling that others can hear your thoughts feeling, seeing, or hearing things that are not there fever with or without chills It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Hydroxychloroquine is associated with macular damage rash and diarrhea Hydroxychloroquine Plaquenil Success, Reviews and Side., Possible Protective Effect of Hydroxychloroquine on Retarding. Can i take pepto bismol with plaquenilPlaquenil cost increaseChloroquine side effects pregnancy Diarrhea, Fever and Skin rash. WebMD Symptom Checker helps you find the most common medical conditions indicated by the symptoms diarrhea, fever and skin rash including Gastroenteritis, Medication reaction or side-effect, and Food poisoning. There are 111 conditions associated with diarrhea, fever and skin rash. Diarrhea, Fever and Skin rash Common Related Medical.. Hydroxychloroquine Oral Route Side Effects - Mayo Clinic. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. I have only been taking Hydroxychloroquine for just over a year and have had no problems. I told the rheumatologist that I had early stages macular degeneration but they said it was not a problem. Recently i have had eye problems, my last eye test was January, so I went back to the optician who sent me to eye casualty. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur.