One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Eye test required for plaquenil Plaquenil depression side effects Plaquenil retinal toxicity oct Hydroxychloroquine mechanism Side Effects Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember. Plaquenil toxicity isn’t even in the top 10, or the top 100” if you’re looking at incidence, he said. “It’s a pretty rare thing.” Nevertheless, he urged doctors to master the Academy’s new guidelines, because the effects from chloroquine and hydroxychloroquine, when they do occur, are severe and often irreversible. End stage hydroxychloroquine toxicity leads to widespread RPE and retinal atrophy with a loss of central vision, peripheral vision, and night vision. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Plaquenil toxicity symptoms Hydroxychloroquine Plaquenil Toxicity and., Rx Side Effects New Plaquenil Guidelines and More - American. Plaquenil and suicidal thoughtsPlaquenil side effects eyes symptoms Sep 13, 2019 Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some. Plaquenil Side Effects Common, Severe, Long Term -. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. What are the symptoms of Plaquenil toxicity?. When using both these tools, keep in mind the following from Melles and Marmor’s recent study 1. “Retinal toxicity from hydroxychloroquine use cannot be completely prevented, but effective screening should recognize retinal toxicity before symptoms or significant risk of central vision loss appear ie. Effects of a Plaquenil overdose may include, but are not limited to Headaches. Drowsiness. Vision changes. Seizures. Cardiac arrest. An irregular heart rhythm arrhythmia. Loss of life. Overdose symptoms may include Headache. Drowsiness. Vision changes. Slow heart rate. Chest pain or heavy feeling. Pain spreading to the arm or shoulder. Nausea. Sweating. Seizure. Shallow breathing. Breathing that stops.