Please review the following URL and make sure that it is spelled correctly. Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine (the active ingredient contained in Plaquenil) may cause some unwanted effects. Hydroxychloroquine patient british Plaquenil and palindromic rheumatoid arthritis Plaquenil and bleeding gums Does plaquenil help discoid lupus SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Long-term studies in animals have not been conducted to evaluate the carcinogenic potential of PLAQUENIL. The mutagenic potential of hydroxychloroquine was not evaluated. However, chloroquine has been shown to be a catalytic inhibitor of DNA repair enzymes topoisomerase II and to produce weak genotoxic effects through this mode of action. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Although not all of these side effects may occur, if they do occur they may need medical attention. Long term plaquenil use Rx Side Effects New Plaquenil Guidelines and More., Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. What is the lowest dose of plaquenilHydroxychloroquine skin darkening BACKGROUND Hydroxychloroquine is used for the treatment of rheumatoid arthritis RA and systemic lupus erythematosus SLE. Long term studies have shown a high rate of termination of hydroxychloroquine treatment in patients with RA. Continuation of long term treatment with.. Hydroxychloroquine Plaquenil. Rx Side Effects New Plaquenil Guidelines and More - American.. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis. According to the Mayo Clinic, it can take up to six months' constant use before an effect is seen in RA 1. If you are taking Plaquenil long-term, such as for an autoimmune condition, your doctor should regularly check you for potential serious side effects. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Important information. Taking Plaquenil long-term or at high doses may cause irreversible damage to the retina of your eye.