Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Chloroquine diphosphate Plaquenil cost increase Chloroquine kidney disorders problems Answer Plaquenil, or hydroxychloroquine HCQ, is an anti-malarial medication that has been proven to be useful in the treatment of patients with rheumatoid arthritis RA, sys- temic lupus erythematosus SLE and other inflammatory and autoimmune diseases. In Sjögren’s syndrome, HCQ is believed to improve oral and ocular eye signs and symp- toms and has been shown to reduce inflammatory markers in saliva and serum, such as sedimentation rates and C-reactive protein levels. But Plaquenil, in it's original form is probably the first "drug discovered by man. As a tree bark, it was chewed to help with the symptoms of malaria and even to prevent malariaand it's still used for both. While in some cases, lower doses of NSAIDS are effective, in rheumatoid arthritis and other forms of inflammatory arthritis a higher dose is often required to decrease inflammation. A lower dosage can initially be used if inflammation is mild, if mechanical pain is the major problem. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Plaquenil help decrease inflammation Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus., Plaquenil and its affect on the immune system DailyStrength Chloroquine mechanism of action lupusDoes plaquenil affect your sleepHydroxychloroquine examPlaquenil and herpes outbreak NSAIDs These anti-inflammatory medications relieve some lupus symptoms by reducing the inflammation responsible for the stiffness and discomfort in your muscle, joints, and other tissues. NSAIDs are milder than many other lupus drugs and may be taken either alone to treat a mild flare or in combination with other medications. Lupus Treatment - Johns Hopkins Lupus Center. Rheumatoid Arthritis Treatment Options Johns Hopkins.. Arthritis - Diagnosis and treatment - Mayo Clinic. Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except. Plaquenil reduces inflammation in many Rheumatic disorders, the mode of action is pretty complicated though so I shan't bore you with all the details, but basically it prevents your dendritic cells these are messengers for your immune system, if you will from interacting with your T-Cells a special type of white blood cell which through a convoluted and boring process, causes inflammation. As part of the inflammatory response, your body increases its production of white blood cells, immune cells, and substances called cytokines that help fight infection. Classic signs of acute short-term inflammation include redness, pain, heat, and swelling.