My rheumy thinks in the long run plaquenil will not be enough for me and I will have to go to the next step. My question is, if plaquenil doesn't work, what is the next step of medication? Chloroquine systemic lupus erythematosus Plaquenil and oral pigmentation Plaquenil and candida Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil is available in generic form. If tranexamic acid doesn’t work for you, or if the side effects are bothersome, your doctor may suggest alternative medications for heavy periods. This might include NSAIDs, a hormonal IUD, oral. Plaquenil takes quite a long time to get to its peak effectiveness depending on what you read, anywhere from 3 months to a year. Unless you are having significant side effects, try to give it at least 6 months before you decide it doesn't work for you. But the way my joint and skin pain has been going I may need bigger guns. Rheumy is very conservative with meds and always looks for the smallest dose possible and the least amount of meds. What if plaquenil doesn't work Does Plaquenil work for anyone? - Sarcoidosis - Inspire, Tranexamic Acid Side Effects and Possible Drug Interactions Plaquenil side effects on liverC1q nephropathy plaquenilDoes plaquenil reduce rheumatoid arthritis Hydroxychloroquine is a one of a number of drugs which have been used for many years in the treatment of malaria. Fortunately, it was discovered these drugs often are helpful in the treatment of various rheumatic diseases, particularly systemic lupus erythematosus SLE or "Lupus" and rheumatoid arthritis. Plaquenil. A medication for Lupus. PLAQUENIL" Rheumatoid Arthritis Community - Support Group. Taking Plaquenil for Rheumatoid Arthritis. Plaquenil-induced toxicity usually will not occur before five years of taking the drug. “Eye damage due to Plaquenil is not common,” he says. “Rarely will anybody who has good vision and minimal symptoms develop loss of central vision or ability to read if annual screening is done and visual are symptoms reported as soon as they occur so. No methotrexate doesn't always mean your hair will fall out or thin but some of the side effects are scary, but before you an progress onto other meds methotrexate is mandatory. for me methotreaxte and plaquenil does't work and i' intonate of sulfa so i am started embrel which states you have to have tried 2 of 3 meds and methotrexate is 1 of them. There are pros and cons for all of them and it's a matter of finding one that suits and one that doesn't give you any intolerable side effects. Make sure you take them on a full stomach. Your doc would help you work out which one might be best for you based on your individual circumstances. Good luck!