Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine-urinaquine Chloroquine classification Plaquenil seronegatice ra Talk to your doctor about this, but my guess is that the Plaquenil is not doing anything to cause the pain, but rather that it is not doing enough to prevent it. It sounds like your RA has probably gotten a bit out of control, relative, to your current treatment, and Plaquenil is not a particularly potent drug when it comes to managing joint pain. Plaquenil is prescribed as a disease-modifier, in other words, to decrease pain, decrease swelling, and prevent joint damage and disability. It is not known how Plaquenil works but researchers believe that Plaquenil interferes with communication between cells within the immune system. Plaquenil is a mild DMARD disease-modifying anti-rheumatic drug that is very commonly prescribed as a "starter drug" for a wide range of autoimmune conditions. It has a very good overall safety profile and is well-tolerated by most people. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil and eye pain The Risk of Retinal Toxicity with Plaquenil, Taking Plaquenil for Rheumatoid Arthritis Hydroxychloroquine copay assistance programChloroquine overdose painfulConcurrent administration of chloroquineLong term effects of hydroxychloroquineHydroxychloroquine sulfate 200 mg brand name Plaquenil is used in the treatment of sarcoidosis but its main use is in the treatment of malaria. One of the side effects of taking the drug is that it affects eye sight, and eye tests, especially field of vision tests need to be done every six months. Plaquenil Withdrawal – Life As An Anomaly. Experiences taking Plaquenil for Fatigue and Muscle Pain.. Plaquenil Uses, Dosage & Side Effects -. Jan 24, 2020 Plaquenil and Eye pain - from FDA reports Summary Eye pain is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 10+ years, also take medication Enbrel, and have Pain. As long as you see your eye care professional regularly, you can feel confident that the plaquenil is safe. If any changes occur in the retina, a dye test is ordered to take pictures of the retina to document any changes noted. Plaquenil Hydroxychloroquine is used to dampen inflammation in some forms of arthritis, especially rheumatoid arthritis and lupus. Plaquenil is usually used for long term disease control, rather than in the short term to control active bursts of inflammation.