Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil rash Does plaquenil lower blood sugar Hydroxychloroquine and colchicine neuromuscular toxicity is well documented. The largest literature review on colchicine myopathy was conducted by Wilbur and Makowsky in 2004 where a database search found 75 cases. Most patients presented with proximal muscle weakness. A wide range of treatment durations were noted from 4 days to 11 yrs with cumulative daily doses of 1.4 ± 0.96 mg. The. Find information about common, infrequent and rare side effects of Plaquenil Oral. Long-term hydroxychloroquine use results in lysosomal dysfunction, which triggers downstream pathophysiological events in the heart resulting in a cardiomyopathy with concentric hypertrophy and conduction abnormalities. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Hydroxychloroquine cardiomyopathy Hydroxychloroquine-Induced Restrictive Cardiomyopathy in a., Common and Rare Side Effects for Plaquenil Oral What is the best time of day to take plaquenil Sep 13, 2017 Hydroxychloroquine HCQ-induced cardiomyopathy is one of the rare but severe complications following prolonged HCQ use. However, the exact mechanism of HCQ cardiotoxicity remains unclear and it is difficult to identify risk factors. Hydroxychloroquine-induced cardiomyopathy and heart failure.. Hydroxychloroquine-Induced Cardiomyopathy Case Report.. Cardiomyopathy Caused by Longterm Treatment with.. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Clinical manifestations of antimalarial-induced cardiotoxicity can manifest as restrictive cardiomyopathy, dilated cardiomyopathy, or conduction abnormalities such as bundle branch and atrioventricular block. Patients usually present with HF symptoms. However, non-specific chest discomfort may be a presenting or coexisting feature. Oct 15, 2012 Hydroxychloroquine HCQ is a 4-aminoquinoline which differs from chloroquine CQ in the addition of a hydroxyl group. Initially used as antimalarials, both drugs have now become mainstays in the management of rheumatic diseases principally systemic lupus erythematosus SLE and rheumatoid arthritis RA.