Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Plaquenil ara Plaquenil cause depression Plaquenil half life Chloroquine retinopathy, is a form of toxic retinopathy damage of the retina caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. This eye toxicity limits long-term use of the drugs. Chloroquine is a 9-aminoquinoline known since 1934. Apart from its well-known antimalarial effects, the drug has interesting biochemical properties that might be applied against some viral infections. Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best. Chloroquine retinopathy is an important complication that may appear even years after cessation of the drug, presenting with impaired visual acuity, central vision loss and progressive damage that could result in irreversible blindness. A detailed patient history that confirms chloroquine use is essential, while advanced ophthalmologic methods must be employed to assess the status of the retina. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine retinopathy ppt PowerPoint Presentation, Effects of chloroquine on viral infections an old drug. Chloroquine malaria dna binding theoryChloroquine resistance prophylaxisPlaquenil canada Hydroxychloroquine and chloroquine work in a similar way as antimalarial medication with different therapeutic and toxic doses and produce a similar pattern of retinopathy. HCQ appears to be considerably less toxic to the retina than CQ, possibly because chloroquine passes the blood – retinal barrier easier 10. Retinal toxicity associated with chronic exposure to hydroxychloroquine.. Chloroquine Retinopathy Symptoms, Diagnosis and Treatment.. Chloroquine Aralen - Side Effects, Dosage, Interactions.. Chloroquine and hydroxychloroquine belong to the quinolone family. They are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity, although their therapeutic and toxic doses differ. Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina. Chloroquine can also induce cataract formation; however, no reports of hydroxychloroquine and cataract have been reported. This article focuses upon hydroxychloroquine retinopathy. Disease ERGs in a patient with chloroquine retinopathy Hydroxychloroquine Plaquenil is usually less disruptive to the retina than chloroquine, but ERG changes can still occur. Other drugs can end up being accidentally toxic to the retina.