Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Generic pill hydroxychloroquine photo Plaquenil and shingles Currently, mebendazole is part of a phase I clinical trial for patients with newly diagnosed, high-grade glioma and glioblastoma. Similarly, the anti-malarial compound chloroquine showed surprising properties in combating cancer and tumor growth in a series of experiments led by a group at the University of Kentucky. In a metastatic cancer mouse model, chloroquine led to the production of a specific tumor suppressor protein called Par-4. Whether to participate in a clinical trial is an important personal decision. Talk with your doctor, ask questions and make sure you get the information you need to feel comfortable about your. The Leukemia & Lymphoma Society Clinical Trial Support Center. This service helps people with leukemia, lymphoma, or myeloma. People connect with support specialists by phone, live chat, or email. And the specialists provide a personalized list of relevant clinical trials. Us TOO Prostate Cancer Clinical Trial Finder. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine cancer clinical trial NCI Drug Dictionary - National Cancer Institute, Top Reasons to Participate in a Cancer Clinical Trial Sponsored Plaquenil and mycophenolatePlaquenil treatment for vasculitisChloroquine phosphate solubilityHydroxychloroquine rare side effectsChloroquine contraindicated pregnancy This trial is looking at adding hydroxychloroquine to chemotherapy for people with small cell lung cancer that has spread. Lung cancer that has spread is called advanced lung cancer. More about this trial One of the treatments for small cell lung cancer SCLC is chemotherapy. A trial of chemotherapy and. - Cancer Research UK. Finding a Clinical Trial Cancer. Net. Chloroquine and hydroxychloroquine for cancer therapy. Cancer cells are thought to use autophagy as a source of energy in the unfavorable metastatic environment, and a number of clinical trials are now revealing the promising role of chloroquine, an autophagy inhibitor, as a novel antitumor drug. On the other hand, however, the kidneys are highly vulnerable to chemotherapeutic agents. Autophagy is a homeostatic cellular recycling system that is responsible for degrading damaged or unnecessary cellular organelles and proteins. Cancer cells are thought to use autophagy as a source of energy in the unfavorable metastatic environment, and a number of clinical trials are now revealing the promising role of chloroquine, an autophagy inhibitor, as a novel antitumor drug. On the. There is a growing evidence that antimalarial chloroquine could be re-purposed for cancer treatment. A dozen of clinical trials have been initiated within the past 10 years to test the potential of chloroquine as an adjuvant treatment for therapy–refractory cancers including glioblastoma, one of the most aggressive human cancers.