It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Long term plaquenil therapy Can plaquenil be used to treat fibromyalgia Drugs administered with chloroquine Chloroquine, and less frequently HCQ, can cause whorllike intraepithelial deposits verticillata in the cornea. These corneal changes are not a direct marker for retinal damage, are not associated with visual loss, and in contrast to retinopathy are usually reversible. Statistical Risk of Toxicity Symptoms and SignsMechanism of ToxicityMedication DosageRisk For ToxicityMonitoring GuidelinesConclusion Deposits in these cells can lead to cutaneous pigmentation and possibly retinal toxicity. Hydroxychloroquine breaks down into two pharmacologically active metabolites — desethyl-hydroxychloroquine and desethyl-chloroquine. After a single dose, hydroxychloroquine is excreted mainly in the faeces, and only 20% is excreted unchanged in the urine. Dose adjustment is therefore only required in patients with severe renal impairment. For prolonged treatment of lupus or arthritis, adverse effects include the acute symptoms, plus altered eye pigmentation, acne, anaemia, bleaching of hair, blisters in mouth and eyes, blood disorders, convulsions, vision difficulties, diminished reflexes, emotional changes, excessive coloring of the skin, hearing loss, hives, itching, liver problems or liver failure, loss of hair, muscle paralysis, weakness or atrophy, nightmares, psoriasis, reading difficulties, tinnitus, skin inflammation and scaling, skin rash, vertigo, weight loss, and occasionally urinary incontinence. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. For short-term treatment of acute malaria, adverse effects can include abdominal cramps, diarrhea, heart problems, reduced appetite, headache, nausea and vomiting. Plaquenil retinal deposits Common and Rare Side Effects for Plaquenil Oral, Hydroxychloroquine-Induced Retinal Toxicity - Hydroxychloroquine for frontal fibrosing alopeciaPlaquenil brain fogRecommended dosage hydroxychloroquine Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Hydroxychloroquine-Induced Retinal Toxicity - American.. Hydroxychloroquine DermNet NZ. Protecting your eyesight when taking Plaquenil. With Plaquenil Plaquenil is manufactured in only a 200 mg tablet The typical dosage is either 200 or 400 mg per day 200 mg daily puts anyone under 68 pounds at risk1 400 mg of Plaquenil daily puts anyone under 135 pounds at a higher risk for toxicity Therefore, 200mg of Plaquenil daily is going to be a safe dosage for virtually all adults13 Initially retinal toxicity due to long-term use of chloroquine Aralen for malaria was reported in 1959 by Hobbs et al. 106 Currently, hydroxychloroquine sulphate Plaquenil is the quinoline agent of choice for the treatment of autoimmune diseases with a far lower incidence of adverse reactions. 107, 108 Hydroxychloroquine has been associated with many ocular toxic effects including keratopathy, ciliary body dysfunction, lens opacities, outer retinal damage, and pigmentary retinopathy. Sometimes Plaquenil can also deposit in the tissues of the body and cause the skin to take on a greenish tone. Dry skin; Loss of appetite; Abdominal bloating; Upset stomach; Stomach cramps; Retinal damage – There is a small chance that retinal damage will occur while taking hydroxychloroquine Plaquenil or chloroquine Aralen.