They are most common among people with weak immune systems. People with certain health conditions may need to take medications with side effects that can weaken your immune system and put you at risk for fungal infections. Hydroxychloroquine win side effects Plaquenil help with fatigue Generic plaquenil manufacturers Hi everyone. Just wondered if anyone can tell me whether hydroxy suppresses the immune system. And if so, to what extent. I know it's not as harsh as some of the other drugs but just wondered what people's experiences are. According to WebMD, in most cases, you don’t need to be worried about drug interactions when taking hydroxychloroquine. It has only a mild effect on the immune system, but you should still tell your doctors what you are taking. Are Drug Interactions a Concern? According to WebMD, in most cases, you don’t need to be worried about drug interactions when taking has only a mild effect on the immune system, but you should still tell your doctors what you are taking. Fungal infections can range from mild to life-threatening. Specifically, corticosteroids and TNF (tumor necrosis factor) inhibitors are two types of medications that can increase your chances of getting a fungal infection. Can hydroxychloroquine interfere with the immune system Will you have Immune system disorder with Plaquenil., RA and Hydroxychloroquine How Effective is it for. Dayquil drug interactions hydroxychloroquine Hydroxychloroquine is a DMARD. The brand name is Plaquenil. What does Plaquenil do? Plaquenil relieves pain and swelling and prevents damage to joints. How long does Plaquenil take to work? Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. RA and Hydroxychloroquine How Effective is it for Rheumatoid.. Does hydroxychloroquine suppress the immune system.. Plaquenil tablets contain the active ingredient hydroxychloroquine, which is a type of medicine called a disease-modifying anti-rheumatic drug DMARD. It is used to treat rheumatoid arthritis. Plaquenil and its affect on the immune system. ddweedee 01/31/2016. I am so confused and in so much pain. My Rheumy started me on Plaquenil 200 mg 1 x day a few months back. After a few weeks I started to feel some pain/joint relief and more energy. Now I just have a few good days versus bad days a week. It alters your immune system, but as far as I know, it doesn't actually suppress it. Plus, if you have only been on it a month, it's probably not built up enough in your body to have much of an effect. I have actually been way HEALTHIER than ever since being on Plaquenil AND Methotrexate, which DOES suppress the immune system - go figure!