Hydroxychloroquine (Plaquenil®) has received little attention in Crohn’s disease (CD). Many anti-inflammatory medications used for rheumatoid arthritis have been applied to inflammatory bowel disease (IBD) therapy. Can you take doxe-pin hcl and hydroxychloroquine 200 mg to Plaquenil and tb test Hearing problems, such as ringing or ticking in the ears, or hearing changes Plaquenil may have toxic effects on your inner ear Loss of balance, coordination, room spinning, or other vertigo. As Kathy said, the Plaquenil can take several months to kick in. I am no physician, but it is my understanding that one of the side effects of Plaquenil can be digestive problems such as you describe. Try to eat some plain crackers and drink a little ginger ale. Club soda with lime is another alternative. People often have some intestinal issues when first starting plaquenil - things generally settle down in a few days. If the issue persists over 10 days call your Dr. Also, it's good to have at least a few bites of food with it. Furthermore it has remained effective for a number of patients for many years (Personal Communication, Lloyd Mayers, MD, 2010). The mechanism of actions that might apply to IBD includes inhibition of T-cells and intracellular stabilization of intracellular inflammation and the immune cascade. Plaquenil and intestinal problems Plaquenil/Hydroxychloroquine and stomach problems?, Plaquenil and Digestive Problems - Reviews Doxycycline and plaquenil interactionsCan you take plaquenil every other day Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia and abnormal red blood cells anemia. Hydroxychloroquine Plaquenil Side Effects & Dosage for.. Plaquenil -. Plaquenil side effects - kidney problems? - Symptoms - Life With Lupus. What are functional gastrointestinal disorders? Functional disorders are those in which the gastrointestinal GI tract looks normal but doesn't work properly. They are the most common problems affecting the GI tract including the colon and rectum. Constipation and irritable bowel syndrome IBS are two common examples. Stomach problems with Plaquenil. April 9, 2007 By Alan Matsumoto, M. D. I started taking Plaquenil 4 weeks ago for non specific autoimmune disease as indicated by ANA. Symptoms were low grade temperature off and on for a year, joint pain and fatigue. Side Effects Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember.