Note the presence of a confluent, erythematous eruption that is not only in a photodistribution but is now on the breasts and upper abdomen. Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine (the active ingredient contained in Plaquenil) may cause some unwanted effects. Statistics about chloroquine Instructions for taking chloroquine Lupus and Photosensitivity When the Sun is Your Enemy If you have lupus, you might be photosensitive – meaning you have an unusually strong reaction to sunlight. In fact, about two-thirds of the people with lupus are UV light-sensitive. The cutaneous manifestations of lupus can include malar rash, discoid rash, and photosensitivity. some may require systemic therapy with an antimalarial agent, such as hydroxychloroquine. 10. Hydroxychloroquine sulfate is a colorless crystalline solid, soluble in water to at least 20 percent; chemically the drug is 2-4-7-Chloro-4-quinolylaminopentylethylamino ethanol sulfate 11. PLAQUENIL hydroxychloroquine sulfate tablets contain 200 mg hydroxychloroquine sulfate, equivalent to 155 mg base, and are for oral administration. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Although not all of these side effects may occur, if they do occur they may need medical attention. Plaquenil photosensitivity rash Photosensitivity Reaction With Certain Medications, Photosensitivity diseases a review of sun-exposed skin rashes Withdrawal symptoms of hydroxychloroquine Rheumatoid Arthritis Medication Beware of Sunburn if You Take These Drugs. A side effect of some RA medicine is sun sensitivity. Be extra careful to avoid skin burns, blistering, and the. Rheumatoid Arthritis Medication Beware of Sunburn if You.. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. Drug-induced photosensitivity DermNet NZ. Re Plaquenil and Sun Exposure Reply #13 on June 12, 2011, AM After a long dark winter of seeing no sun, I finally went into the sun for an hour, early in the morning, and over the next day, developed a red raised rash on all exposed parts, a rash that lasted for several weeks. Plaquenil can improve photosensitivity. However imuran and other immunosuppressants, which I also take can worsen it. Thankfully for me that didn't happen and I still have a huge improvement on what I was like before where I would break out in a severe hive or blister like rash anywhere that was exposed." This rash is typically seen on the nose and cheeks, called a malar rash, and is considered one of the hallmarks of lupus. Porphyria is another medical condition that may cause photosensitivity reactions. This is a hereditary condition with skin manifestation cutaneous porphyria causing rashes and blisters in reaction to exposure to sunlight.