Chikungunya disease and chloroquine treatment

Discussion in 'Generic Chloroquine' started by delph, 25-Feb-2020.

  1. maramasas666 Well-Known Member

    Chikungunya disease and chloroquine treatment


    Listing a study does not mean it has been evaluated by the U. Most of cases are expressed as a mild disease, with intense fever and arthralgias, with rare but serious complications (encephalitis, liver, cardiac or renal failures.) having required a hospitalization in an intensive care unit. A severe outbreak of Chikungunya fever has been reported at La Réunion Island (France) in 2005-2006. Chikungunya virus is an alphavirus transmitted to humans by the bite of infected mosquitoes, usually of the genus Aedes (Aedes albopictus in La Réunion).

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    It turns out that the Centers for Disease Control and Prevention CDC has known since at least 2005 that chloroquine is effective against coronaviruses. In 2005, Martin J Vincent et al published a study in Virology Journal titled ‘Chloroquine is a potent inhibitor of SARS coronavirus infection and spread.’ Here are its findings In recent issues, the efficacy of chloroquine and the dosage that may be used in the treatment of acute chikungunya infections was discussed. We have conducted a double-blind placebo-controlled randomized trial on the French Reunion Island Indian Ocean, in which 27 patients received chloroquine and 27 patients received a placebo treatment. To evaluate whether chloroquine CQ is more effective than meloxicam for treating early musculoskeletal pain and arthritis following acute chikungunya CHIK virus infection. Methods. During the 2006 CHIK epidemic, 509 rural community cases of acute CHIK virus infection were identified in the district of Sholapur in India.

    Chikungunya was proven in 246 serious cases; 101 patients had comorbidities, and 27% of confirmed cases eventually died. 273 of such serious cases (immediately life threatening condition) have been reported among the cases, in patients aged over 10 days (59% were 65 age old).

    Chikungunya disease and chloroquine treatment

    Chikungunya fever Treatment and prevention - UpToDate, On Chikungunya Acute Infection and Chloroquine Treatment.

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  3. Chloroquine treatment for five days in patients with acute chikungunya did not protect against sever e disease. Moreover, the first analysis has shown that chronic arthralgia on day 300 post.

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    Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Occasionally it is used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. CuraChik A Trial of the Efficacy and Safety of Chloroquine as Therapeutic Treatment of Chikungunya Disease The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Chikungunya is an infection caused by the chikungunya virus CHIKV. Symptoms include fever and joint pains. These typically occur two to twelve days after exposure. Other symptoms may include headache, muscle pain, joint swelling, and a rash.

     
  4. TestPilot Well-Known Member

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