Chloroquine torsades

Discussion in 'Health Canada Drug Database' started by ninanikolaivnazz, 06-Mar-2020.

  1. Pacak Well-Known Member

    Chloroquine torsades


    It is a polymorphic ventricular tachycardia that exhibits distinct characteristics on the electrocardiogram (ECG). Symptoms and consequences include palpitations, dizziness, lightheadedness (during shorter episodes), fainting (during longer episodes), and sudden cardiac death. Torsades occurs as both an inherited (linked to at least 17 genes) Common causes for torsades de pointes include drug-induced QT prolongation and less often diarrhea, low serum magnesium, and low serum potassium or congenital long QT syndrome.

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    Chloroquine enters the red blood cell by simple diffusion, inhibiting the parasite cell and digestive vacuole. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion. The most important thing to mention about the management of torsade de pointes is that there is essentially no evidence. The best available evidence is for the standard ACLS algorithm, with no differentiation made between torsades and standard monomorphic ventricular tachycardia. A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen.

    Certain drugs and combinations of drugs resulting in drug interactions are common contributors to torsades de pointes risk. It can be seen in malnourished individuals and chronic alcoholics, due to a deficiency in potassium and/or magnesium.

    Chloroquine torsades

    Causes and management of torsades de pointes, Torsades de Pointes Approach to resuscitation - First10EM

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  7. Erythromycin is a macrolide antibiotic that is widely used for various infections of the upper respiratory tract, skin, and soft tissue. Similar to other macrolides clarithromycin, azithromycin, erythromycin has been linked to QTc interval prolongation and torsade de pointes TdP arrhythmia.

    • Erythromycin, QTc interval prolongation, and torsade de..
    • Chloroquine Indications, Side Effects, Warnings -.
    • DRUGS TO BE AVOIDED BY CONGENITAL LONG QT PATIENTS.

    The aim of the study. This publication provides an overview of published clinical studies results on pharmacokinetic and/or pharmacodynamic drug-drug interactions in humans either healthy volunteers or patients and their electrophysiological consequences manifested as change in the QT/QTc interval. Torsades de pointes or torsade de pointes TdP French tɔʁsad də pwɛ̃t, translated as "twisting of peaks", is a specific type of abnormal heart rhythm that can lead to sudden cardiac death. It is a polymorphic ventricular tachycardia that exhibits distinct characteristics on the electrocardiogram ECG. Nov 25, 2019 Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito.

     
  8. tigerzombi Well-Known Member

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Plaquenil Hydroxychloroquine Side effects, Images, Uses. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Rheumatoid Arthritis Treatment Side Effects
     
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  10. sea-tm XenForo Moderator

    Plaquenil hydroxychloroquine sulfate dosing, indications. Not for administration with other drugs that have potential to prolong QT interval; hydroxychloroquine prolongs QT interval; ventricular arrhythmias and torsades de pointes reported in patients taking hydroxychloroquine Skeletal muscle myopathy or neuropathy leading to progressive weakness and atrophy of proximal muscle groups.

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