Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Risks of plaquenil Can hydroxychloroquine stop bone graft osseointegration Severe and irreversible retinal damage has been reported with the use of hydroxychloroquine. Risk factors for retinal damage include daily doses more than 6.5 mg/kg 5 mg/kg base of actual body weight, durations of use greater than 5 years, subnormal glomerular filtration, use of concomitant drugs such as tamoxifen, and concurrent macular disease. Many people have nausea, stomach cramps, and diarrhea when they first start taking Plaquenil hydroxychloroquine. If you have heart, eye, liver conditions, or psoriasis, talk to your doctor to see if Plaquenil hydroxychloroquine is right for you. Chlorpheniramine; Codeine Moderate Concomitant use of codeine with hydroxychloroquine may increase codeine plasma concentrations, but decrease the plasma concentration of the active metabolite, morphine, resulting in reduced efficacy or symptoms of opioid withdrawal. It is recommended to avoid this combination when codeine is being used for cough. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil tamoxifen symptoms reticulocytosis Plaquenil Oral Uses, Side Effects, Interactions, Pictures, Warnings., Compare Plaquenil vs Chloroquine - Plaquenil and birth control A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including rash, itching/swelling especially of the face/tongue/throat, dizziness, trouble breathing. This is not a complete list of possible side effects. Plaquenil Oral Uses, Side Effects, Interactions, Pictures.. Plaquenil hydroxychloroquine sulfate dose, indications.. Hydroxychloroquine-Induced Retinal Toxicity - American.. Mar 17, 2019 Get emergency medical help if you have signs of an allergic reaction to hydroxychloroquine hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Summary Drug interactions are reported among people who take Plaquenil and Tamoxifen citrate together. This study is created by eHealthMe based on reports of 55 people who take Plaquenil and Tamoxifen citrate from Food and Drug Administration FDA, and is updated regularly. Hydroxychloroquine Plaquenil is a disease-modifying antirheumatic drug that is commonly used to reduce arthritic pain and swelling. Signs and symptoms. “The association of Plaquenil therapy with macular toxicity is well established,” said Michael F. Marmor, MD, at the Byers Eye Institute at Stanford University.