Chloroquine bull's eye maculopathy guidelines

Discussion in 'Hydroxychloroquine Sulfate 200 Mg' started by Ledon, 19-Mar-2020.

  1. pilotvlgts Well-Known Member

    Chloroquine bull's eye maculopathy guidelines


    She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation.

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    Bull's-eye maculopathy has been associated with various macular diseases, most notably chloroquine and hydroxychloroquine maculopathy, cone dystrophy, and Stargardt disease. 1-4 To our knowledge, bull's-eye maculopathy associated with chronic macular holes has not been previously reported. H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. The most common side effect associated with its use is retinal toxicity, which may be irreversible. Forty-seven year-old male patient with medical history of psoriatic arthritis treated with chloroquine. Visual acuity was of counting fingers. Color fundus photos showing bull's-eye maculopathy and optic nerve atrophy associated with chloroquine toxicity.

    Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use.

    Chloroquine bull's eye maculopathy guidelines

    Macular Telangiectasia A cause of bull’s eye maculopathy, Retinal Physician - Hydroxychloroquine Maculopathy An.

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  4. The American Academy of Ophthalmology released an updated set of screening recommendations for hydroxychloroquine Plaquenil and chloroquine to account for the many studies that have shown the effects of these medications on the retina 1. It succinctly makes the case for screening, and

    • Hydroxychloroquine And Chloroquine Screening 2016 AAO..
    • Bull's-eye maculopathy - American Academy of Ophthalmology.
    • Hydroxychloroquine toxicity - EyeWiki.

    Bull's-eye maculopathy due to hydroxychloroquine toxicity. Chloroquine and hydroxychloroquine can cause toxic retinopathy due to their binding of melanin in the retinal pigmented epithelium RPE as well as direct toxicity to retinal ganglion cells. Early findings include mottling of the RPE and blunted foveal reflex. These findings were consistent with bull's eye maculopathy, a classic feature of advanced hydroxychloroquine toxicity. 3 months after medication was stopped, the patient's visual acuity had remained stable, and no other complaints were reported. And before treatment is initiated with hydroxychloroquine, a complete ophthalmic examination should be performed to determine any baseline maculopathy. Ophthalmologists should also follow the most current screening guidelines established by the Academy, 1 recently revised in light of new findings. Symptoms and Signs. Symptoms.

     
  5. nixm XenForo Moderator

    Selected from data included with permission and copyrighted by First Databank, Inc. Treatment Options for Sjogren Syndrome Arthritis Foundation Study Raises Questions about Sjogren's and Plaquenil Sjogren's Syndrome Symptoms, Causes, Diagnosis, Treatment
     
  6. Liopik User

    Background: The American Academy of Ophthalmology recommendations on screening for chloroquine (CQ) and hydroxychloroquine (HCQ) retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. ICD-10-CM Diagnosis Code Z79.899 Other long term. Recommendations on Screening for Chloroquine and. My Take on New Ocular Screening Guidelines for Plaquenil.
     
  7. LanSib User

    Hydroxychloroquine versus phlebotomy in the treatment of. It is concluded that hydroxychloroquine is more effective than phlebotomy in decreasing porphyrin production. However, further work is needed to assess whether long‐term hydroxychloroquine treatment favours the progression of the chronic liver disease associated with PCT.

    Hydroxychloroquine Uses, Dosage & Side Effects -
     
  8. pingo Well-Known Member

    Epsom Salt Uses, Side Effects & Warnings - Using too much Epsom Salt can cause serious, life-threatening side effects. Epsom Salt may be used orally by mouth or as a soak. Follow your doctor's instructions or the directions on the package. To take Epsom Salt orally, dissolve one dose in 8 ounces of water. Stir this mixture and drink all of it right away.

    Aquarium Fish Chloroquine A "New" Drug for Treating Fish.