Chloroquine glutathione synthase

Discussion in 'Hydroxychloroquine Sulfate' started by asf, 05-Mar-2020.

  1. deadlog New Member

    Chloroquine glutathione synthase

    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    The systematic name of this enzyme class is gamma-L-glutamyl-L-cysteineglycine ligase ADP-forming. Other names in common use include glutathione synthetase, and GSH synthetase. This enzyme participates in glutamate metabolism and glutathione metabolism. At least one compound, Phosphinate is known to inhibit this enzyme. Keeping that statement in mind I will address foods that can aid in glutathione synthesis. The first step in producing glutathione is catalyzed by gamma-glutamylcystein synthase. This enzyme binds cysteine to the gamma carbon of glutamate which forms gamma-glutamylcystein. The genes encoding enzymes involved in glutathione GSH metabolism may modulate responses to antimalarial drugs, but the role of most of them in antimalarial drug resistance has scarcely been investigated.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine glutathione synthase

    Glutathione Synthetase Deficiency - NORD National., Glutathione Synthesis and Diet - Robb Wolf

  2. Hydroxychloroquine hypokalemia
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  5. The tripeptide thiol glutathione GSH is at the hub of the complex antioxidant networks of plant and animal cells, participating in cellular redox signalling networks that influence growth, development and defence Foyer and Noctor, 2005; Maughan and Foyer, 2006. Glutathione has long been implicated in the control of growth in animals and plants.

    • Recruitment of glutathione into the nucleus during cell proliferation..
    • Is the expression of genes encoding enzymes of glutathione..
    • Chloroquine - Wikipedia.

    Glutathione biosynthesis involves two adenosine triphosphate-dependent steps First, gamma-glutamylcysteine is synthesized from L-glutamate and cysteine. This conversion requires the enzyme glutamate–cysteine ligase GCL, glutamate cysteine synthase. This reaction is the rate-limiting step in glutathione synthesis. Chloroquine is a lysosomotropic weak base, which in the monoprotonated form diffuses into the lysosome, where it becomes diprotonated and becomes trapped. Protonated chloroquine then changes the lysosomal pH, thereby inhibiting autophagic degradation in the lysosomes. Glutathione synthetase is also a potent antioxidant. It is found in many species including bacteria, yeast, mammals, and plants. In humans, defects in GSS are inherited in an autosomal recessive way and are the cause of severe metabolic acidosis, 5-oxoprolinuria, increased rate of haemolysis.

  6. burov New Member

    Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). Hydroxychloroquine MedlinePlus Drug Information Hydroxychloroquine Uses, Dosage & Side Effects - HYDROXYCHLOROQUINE - ORAL Plaquenil side effects, medical.
  7. seregga Moderator

    Plaquenil Las Vegas Diabetic Retinopathy Wellish Vision Institute If you are using Plaquenil, The Wellish Vision Institute recommends regular eye exams to help catch any change that may be subtly occurring. Symptoms of retinopathy to be aware of are blind spots in your central vision, distortion of objects, blurring, light flashes and sensitivity, as well as colors becoming distorted and difficulty seeing at night.

    Hydroxychloroquine toxicity - EyeWiki