Why is p falciparum resistance to chloroquine

Discussion in 'International Pharmacy' started by trafimka, 16-Mar-2020.

  1. detped XenForo Moderator

    Why is p falciparum resistance to chloroquine


    Chloroquine was first discovered in the 1930s in Germany and began to be widely used as an anti-malaria post-World War II, in the late 1940s. However, resistance to the drug also rapidly emerged, with the first cases of not being cured by administration of chloroquine being reported in the 1950s.

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    P. falciparum or Species Not Identified – Acquired in Areas Without Chloroquine Resistance. For P. falciparum infections acquired in areas without chloroquine-resistant strains, which include Central America west of the Panama Canal, Haiti, and the Dominican Republic, patients can be treated with oral chloroquine. We believe that our results, besides shedding light on the mechanism of chloroquine resistance in P. falciparum, have implications for the development of novel therapies against resistant malaria strains and demonstrate the usefulness of an approach combining systems biology strategies with structural bioinformatics and experimental data. Efficacy studies of antimalarial drugs done in India since 1978 show that resistance of P falciparum to chloroquine increased over time and is present across all regions of the country. Efficacy of sulfa–pyrimethamine for treatment of P falciparum was reduced in some recent studies, largely in the northeast.

    Nowadays, other drugs, and notably ones containing artemisinin-based compounds, are preferentially used to treat uncomplicated malaria and especially in areas where chloroquine resistance is known to occur. Since then, resistance has spread rapidly (since obviously it is beneficial to the parasite to be resistant, so various mutations conferring this protection have arisen multiple times in different areas in the world and also been passed on preferentially to new generations of malaria parasites), and now chloroquine resistant are found in multiple locations in south-east Asia, such as Myanmar and India, as well as from Guyana in South America.

    Why is p falciparum resistance to chloroquine

    Drug Resistance in the Malaria-Endemic World - CDC, On the Mechanism of Chloroquine Resistance in Plasmodium.

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  5. Treatment of uncomplicated falciparum malaria, only in areas where P. falciparum is still sensitive to chloroquine Central America, Haiti and Dominican Republic – Prophylaxis of falciparum malaria for non-immune individuals, only in areas where resistance to chloroquine is moderate and always in combination with proguanil. Forms and.

    • CHLOROQUINE sulfate or phosphate oral - Essential drugs.
    • Antimalarial drug resistance of Plasmodium falciparum in..
    • Chloroquine-Resistant Malaria The Journal of Infectious..

    These reports of chloroquine-prophylaxis or treatment failures were substantiated by serial parasitologic and clinical observations of each infection and, when available, in-vitro confirmation of drug resistance. CDC continues to monitor the status of chloroquine-resistant P. falciparum malaria in East Africa 2. The samples were processed and analysed using genes–P. falciparum chloroquine-resistant transporter pfcrt and P. falciparum multidrug resistance 1 pfmdr1 via sequencing of PCR amplicon from 2015 to 2017. Malaria occurred throughout the year and P. falciparum accounted for 89% of total malaria cases. Chloroquine is the drug of choice for travel to areas where chloroquine resistance has not been described. Chloroquine is active against the erythrocytic forms Fig. 6.3 of sensitive strains of all species of malaria, and it is also gametocidal against P. vivax, P. malariae, and P. ovale.

     
  6. venivediwow New Member

    Benefits include even better soft lens searches and helpful contact lens calculators (including RGPs and cross cylinders). ACR Actual-weight hydroxychloroquine dosing works in SLE. Hydroxychloroquine toxicity - EyeWiki Hydroxychloroquine MedlinePlus Drug Information
     
  7. kudnalgne Well-Known Member

    Undifferentiated Connective Tissue Disease Mayo Clinic. I'm no medical expert and have no training but I think the term undifferentiated connective tissue disease UCTD is similar to use of the term idiopathic for a diagnosis that's not specific. Here are a few articles I found using Google Scholar.

    Undifferentiated Connective Tissue Diseases - Lupus Research