Both medications are commonly used to treat patients with systemic autoimmune diseases that include the following: The pathogenic effect of plaquenil is the induction of lysosomal dysfunction in photoreceptors and retinal pigment epithelium (RPE) cells. A lysosome is a membrane-bound organelle found in the cytoplasm of most cells and it contains hydrolytic enzymes that function in intracellular digestive processes. Calcium and plaquenil Sanofi aventis plaquenil Chloroquine in hepatic dysfunction Photoreceptor Integrity Line PIL - Presence or loss in foveal area is predictive of visual fn. Plaquenil Screening 2016 Guidelines A. Choroid-Sclera. Photoreceptor dysfunction may be a significant predictor of visual acuity in a spectrum of surgical and medical retinal diseases. This review aims to provide an overview and summarizes the role of the photoreceptor inner segment ellipsoid band in the management and prognostication of various vitreoretinal diseases. Purpose To evaluate the integrity of the photoreceptor inner segment and outer segment IS/OS junction using spectral-domain optical coherence tomography SD OCT in patients with diabetic macular edema and to correlate the relationship between the integrity of the IS/OS junction and visual acuity. Design Observational, prospective study. In the normal retina, the retinal pigment epithelium digests the tips of the photorectors by lysosomal action. When hydrolytic enzymes are released into the cytoplasm, they cause self-digestion of the cell. Photoreceptor integrity line plaquenil Caring for the Plaquenil Patient - Course Exam, Photoreceptor inner segment ellipsoid band integrity on. Benefits of hydroxychloroquine The line scans show loss of the photoreceptor integrity around the macula in both eyes. Photos confirm clinical findings. FLUORESCEIN ANGIOGRAPHY Fluorescein angiography shows a classic bull’s eye maculopathy in each eye from the Plaquenil toxicity. Plaquenil Toxicity - Home - Retina Gallery ~ Full Sized Retina Images. The relationship between photoreceptor IS/OS junction changes and.. So You Think Checking For Plaquenil Toxicity Will Not Make.. Attenuation, discontinuity or disruption of these bands have been reported as likely hallmarks of photoreceptor dysfunction or damage in a variety of retinal diseases. 6,14,16 These changes are better assessed in the absence of features that could weaken the signal intensity of the outer retinal layers, such as retinal edema, hemorrhage or media opacity. So You Think Checking For Plaquenil Toxicity Will Not Make A Difference? A STORY THAT NEEDS TO BE TOLD. Recently new guidelines for the management of patients taking PLAQUENIL were released. The photoreceptor integrity line is important, because it’s a biomarker of photoreceptor integrity, both rods and cones. And the term PIL for the receptor integrity line does not limit the usefulness of the concept of a biomarker, regardless of the precise anatomical location, which is subject to debate and change. So the right photoreceptor.