ANSWER Chloroquine-resistant malaria is exactly what it sounds like—particular types of malaria which are not cured by treatment with chloroquine. Chloroquine was first discovered in the 1930s in Germany and began to be widely used as an anti-malaria post-World War II, in the late 1940s. How to admin chloroquine Plaquenil screening guidelines ophthalmology Since then, resistance has spread rapidly since obviously it is beneficial to the parasite to be resistant, so various mutations conferring this protection have arisen multiple times in different areas in the world and also been passed on preferentially to new generations of malaria parasites, and now chloroquine resistant P. falciparum can. The geographical distributions and rates of spread have varied considerably. P. vivax has developed resistance rapidly to sulfadoxine-pyrimethamine in many areas. Chloroquine resistance is confined largely to Indonesia, East Timor, Papua New Guinea and other parts of Oceania. Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Since then, resistance has spread rapidly (since obviously it is beneficial to the parasite to be resistant, so various mutations conferring this protection have arisen multiple times in different areas in the world and also been passed on preferentially to new generations of malaria parasites), and now chloroquine resistant are found in multiple locations in south-east Asia, such as Myanmar and India, as well as from Guyana in South America. However, resistance to the drug also rapidly emerged, with the first cases of not being cured by administration of chloroquine being reported in the 1950s. Chloroquine resistance areas Update Chloroquine-Resistant Plasmodium falciparum -- Africa, Chloroquine C18H26ClN3 - PubChem Typical plaquenil dosagePlaquenil for chronic hivesChloroquine dna transfectionDayquil drug interactions hydroxychloroquineRetinopathy symptoms from plaquenil DRUG RESISTANT MALARIA Chloroquine resistance Chloroquine is ineffective in almost all malaria endemic countries In India chloroquine resistance was first detected in 1973 in Assam. Severe in northeast and southeastern regions of India with high morbidity and mortality. DRUG RESISTANT MALARIA CURRENT STATUS. Chloroquine Uses, Side Effects & Warnings -. Chloroquine-Resistant Malaria The Journal of Infectious Diseases.. Chloroquine phosphate tablets are indicated for the Treatment of uncomplicated malaria due to susceptible strains of P. falciparum, P.malariae, P. ovale, and P.vivax. Prophylaxis of malaria in geographic areas where resistance to Chloroquine is not present. Treatment of extraintestinal amebiasis. Read the original article in full on AAS Open Research Prevalence of chloroquine and antifolate drug resistance alleles in Plasmodium falciparum clinical isolates from three areas in Ghana Drug resistance has been implicated in the spread of malaria to new areas and re-emergence of malaria in areas where the disease had been eradi-cated. Drug resistance has also played a significant role in the occurrence and severity of epidemics in some parts of the world. Population movement has introduced resistant parasites to areas.