It also associated with rheumatic disorders such as rheumatoid arthritis, and it is rheumatoid factor positive in 90 percent of cases. Reading the warnings, I see that there is concern about effects on the eyes (retinas). I am very concerned about this and am wondering if anyone out there has been put on an alternative drug to treat their SS. Plaquenil sleep disturbance Plaquenil and smoking Plaquenil chronic hives Chloroquine maculopathy dose To prevent upset stomach, take Plaquenil with food. Also, the generic version of Plaquenil, hydroxychloroquine, can cause additional stomach irritation. If you are experiencing consistent stomach aches, it may be useful to talk to your doctor about taking the brand-name alternative. Alternatives to Plaquenil A few weeks ago I was out in the sun for 10 minutes and developed a rash all over my feet and legs and flared up the next day. On Saturday I was out in the sun for about 5 minutes and then threw up, had a severe migraine and dizzy and weak. I have a long list of medication that I am allergic to including NSAIDs and plaquenil. A few years ago at the time she finally had enough evidence to call lupus not zero-negative RA we tried methotrexate. The starter dose landed me in hospital with anaphylaxis. Because of this my rheumatologist is very hesitant to play around with my meds. The side effects of these medications are far scarier! I have several issues with my retinas already, and don't feel comfortable putting them at more risk. There are other medications but they're usually saved for those with a more severe disease, particularly joint problems. Alternatives to plaquenil for lupus Discontinuing Plaquenil. any other options?, Healthboards - Immune & Autoimmune - Lupus Alternatives to What does plaquenil do for sjogren& 39 For reasons not yet completely understood, it can also suppress the immune response in lupus. Plaquenil is used to treat fatigue, pain, skin rashes, and inflammation, especially around the lungs. It is one of the most frequently used medications for lupus because studies show that it may prevent lupus flares and kidney damage. Lupus Treatment Options Lupus Medications - Kaleidoscope.. Alternatives to Methotrexate lupus. Alternative" to plaquenil. ProHealth Fibromyalgia, ME/CFS.. The alternative to Plaquenil is a slightly different anti malarial called Quinacrine. Plaquenil replaced Quinacrine formerly called Atabrine for anti malarial prophylaxis so now the Quinacrine has to be made up into pills or gel capsules by a compounding pharmacy. If you google you will find details of compounding pharmacies. Substitutes and alternatives to Plaquenil hydroxychloroquine for uses like Rheumatoid arthritis, Lupus and Malaria Plaquenil hydroxychloroquine Alternatives & Similar Drugs - Skip to full site navigation Hello! Here is a short list Prednisone, Imuran, Remicade, Methotrexate Later sidesteps Prednisone's side effects, which include weight gain, mood swings, diabetes and eye problems, such as cataracts. I hope this was helpful enough.