Had symtoms of malar rash, joint pain especially in hands, fatigue , dry eyes and dry skin . Had a biopsy of skin and confirmed cutaneous lupus. I was put on Plaquenil and for the past 8 years I have been fine with it . Now this year I have been having things pop up that are related to a low immune system. Plaquenil for sle Is plaquenil the same as hydroxychloroquine Arthritis plaquenil Definition NCI A 4-aminoquinoline with immunosuppressive, antiautophagy, and antimalarial activities. Although the precise mechanism of action is unknown, hydroxychloroquine may suppress immune function by interfering with the processing and presentation of antigens and the production of cytokines. Unlike other DMARDs, Plaquenil does not suppress the immune system. It changes something within the cell to decrease the inflammation. I've been on it 6 months and my joints, fatigue and nose/mouth ulcers have improved. I've had one cold since then, which isn't more than usual for me. The number of patients taking immunosuppressive drugs for the management of autoimmune inflammatory conditions is increasing. The general practitioner needs to be active in preventing, monitoring and managing the adverse effects of these drugs even long after the treatment has ceased. Does anybody have any input concerning taking Plaquenil for long term therapy ? Some of my doctors think It is the Plaquenil causing it but then some say that Plaquenil is not an immunosuppressant drug that for some reason my immune system is out of wack . I tried to only take 100 mg to see if it would make a difference but I started with terrible joint pain and fatigue so I am back on the 200 mg a day. Hydroxychloroquine immune suppressant Is Plaquenil a immunosuppressant drug ? Autoimmune., Anyone on Hydroxychloroquine plaquenil - Autoimmune. Plaquenil safer than floroquinolonesPlaquenil assistance programDoes plaquenil cause leg pain Overall, most serious fungal infections are rare, but they do happen. They are most common among people with weak immune systems. People with certain health conditions may need to take medications with side effects that can weaken your immune system and put you at risk for fungal infections. Medications that Weaken Your Immune System and Fungal.. Long-term management of patients taking immunosuppressive.. Hydroxychloroquine - Wikipedia. A recent large study of people with cardiovascular disease found that hydroxychloroquine Plaquenil does not increase the risk of infection and methotrexate increases the risk of infection only slightly. The concern with immune suppression is that the virus could replicate more freely and cause more severe or extensive disease, says Dr. Winthrop. Immunosuppressant drugs are a class of drugs that suppress, or reduce, the strength of the body’s immune system. Some of these drugs are used to make the body less likely to reject a. Howdy LadyDi, sorry you are having problems. Plaquenil is what is call an immune modifier. It is not a immune suppressant. Originally it was used to prevent Malaria. Then it was discovered to be effective for the treatment of Lupus. Plaquenil has the least amount of side affects in treating auto immune disorders.