I hear Ashwaganda or other herbal adaptogens might ease my anxiety/depression and give me more energy. Give Zoloft is the longer effective for you you might ask your doctor about Celexa. Anyway, I tapered with Doctor's supervision and went through 'electric shocks' headaches and nausea etc. As for the answer to the second part of your question. In addition I feel fatigue all the time, I want to sleep all the time it seems. I would not suggest herbal substitutes because they had not been well studied and the dosage has not been standardized so you do not know what you're getting and how much you are getting. I was on it a year and tired of the sexual dysfunction and mental nullity- I'm a freelance writer and wrote nothing for that whole year- couldn't do it. Now it's six weeks since my last dose and still I'm getting celexa-like symptoms- nausea and head rushes, muscle-stiffness and jerky spasms on going to bed. I have been taken Zoloft for about 8 years now and my doctor had suggested to take the Zolof at bed time. I ask myself whether this can be a long term upshot of the drug- my doctor is *very* circumspect about that. This way if it makes you sleepy and tired, your taking it at the best time. I have tried all herbal alternatives and found that none work. Everyone say's that after your body is use to the medication you will do just fine, and it's said that it usually takes about two weeks. I am still waiting for Zoloft to work, I still feel depressed most of the time, all Zoloft seems to do is make me tired. Don't get discuraged - it took me about 6 weeks and let me tell you I'm glad I didn't give up and waited it out. I have tried taking it at night and it makes no difference. 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