Levitra, or vardenafil, is one of several oral medications used to treat erectile dysfunction, or ED. Levitra belongs to a class of agents called phosphodiesterase-5, or PDE5, inhibitors. Food and Drug Administration in August 2003 and soon after joined other drugs on a growing list of medications that interact with grapefruit. Like all drugs in this class, Levitra improves blood flow to the penis, thereby helping maintain an erection to permit sexual intercourse. PDE5 is an enzyme found in several tissues, including your blood vessels, lungs, intestines and eyes. It is found in particularly high concentrations in the smooth muscle cells lining the blood vessels of your penis. PDE5 breaks down a molecule called c GMP, thereby reducing your cells’ ability to produce nitric oxide. Nitric oxide promotes blood vessel dilation, which enhances blood flow to the penis and improves erectile function. By blocking PDE5, Levitra increases c GMP levels, boosts nitric oxide production and strengthens erections. Like many drugs, Levitra is partially metabolized by a specific enzyme, called CYP3A4, in the lining of your intestine. cialis onset Using vardenafil together with nitroglycerin is not recommended. Combining these medications may cause blood pressure to fall excessively, which can lead to cardiovascular collapse. The risk of other side effects such as dizziness, lightheadedness, fainting, headache, flushing, heart palpitations, and priapism (prolonged and painful erection unrelated to sexual activity) may also increase. You should seek immediate medical attention if you experience chest pain or tightness during treatment with vardenafil. Do not use nitroglycerin on your own without consulting your doctor, even if it has been a few days since you have taken a dose of vardenafil. It is important to tell your doctor about all other medications you use, including vitamins and herbs. 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You may be more likely to experience symptoms such as dizziness, lightheadedness, fainting, flushing, headache, and heart palpitations. You should avoid or limit the use of alcohol while being treated with vardenafil, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor. Switch to professional interaction data Grapefruit juice may increase the blood levels of certain medications such as vardenafil. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with vardenafil. 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