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There are many alternatives to zoloft, including celexa, prozac, paxil, (paroxetine) lexapro, etc. If zoloft is being used for depression, exercise may also be an alternative to zoloft and other ssri's. The "best" medicine for you depends on a thorough psychiatric evaluation and careful selection based on your individual needs. In this, your doctor also considers other medicines you're taking. Read more See 1 more doctor answer Lexapro (escitalopram) is an SSRI and there are countless other meds in this group of drugs that can help. Read more This is best discussed with the patient's provider. Sometimes what works for one person or at one time does not help someone else. Is it tendon or joint problems, gastrointestinal issues, or sensitivity? If the depression is atypical, wellbutrin (bupropion) is a good choice. However, others in the group of meds may be very effective. Wellbutrin (bupropion) is used an antidepressant, but there are many better known medications to use than inositol. Check with the physician who prescribed the wellbutrin (bupropion). Read more See 1 more doctor answer Levaquin is a 3rd generation floroquinalone and is used for many conditions. For typical depression or anxiety - a selective serotonin reuptake inhibitor can be used. Lexapro (escitalopram) is approved for treatment of major depression ; generalized anxiety disorder but some doctors use it off label for panic disorder ; agoraphobia. Read more Lexapro and other ssri medications are considered first line treatment for a variety of anxiety disorders. There are also other classes of antidepressants that you can discuss with your doctor. If the person needs something more on the sedating side - a medication like Remeron may be considered. 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